So far so good, as far as I can tell with the new system. I'm a sage and appear to be behind in scientists but I've played most ages with underwhelming science. That is to say, I've found ways to compensate poor science with more assertive play for several ages.
One thing I don't do is put all my eggs in one basket. By levying my subtle advantages I find the edge I require to overtake many opponents. At worst I've had to batten down the hatches but never been blown out of a conflict due to science.
When I've needed intel I've gotten it. When I've cast spells they've landed at a decent percentage. My economy is fairly solid. I haven't tweaked anything except beginning of age and moved food scientists elsewhere since I'm undead. Other than this I'm semi-pumping as usual. If a scientist lands in anything but food ;-) I leave them there just to see where it leads. I'm fully able to attack and I'm working on being even more formidable casting via wiz pump.